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Christian A. Gleissner, M.D.

A model of macrophage phenotypes within atherosclerotic lesions. Department of Cardiology
Heidelberg University
Im Neuenheimer Feld 410
69120 Heidelberg
Phone +49-6221-568611
Fax +49-6221-565515
Email: christian.gleissnermed.uni-heidelberg.de

Email: christian.gleissnermed.uni-heidelberg.de

Web Site: www.klinikum.uni-heidelberg.de

Summary
Our lab studies the role of the immune system in cardiovascular disease. The main focus of the lab is on atherosclerosis. We are specifically interested in the role of monocytes, monocyte-derived macrophages and dendritic cells. This includes interaction with other immune cells such as T lymphocytes as well as the function of specific cytokines and chemokines. Our goal is to identify novel pathomechanisms of atherogenesis, which may result in novel diagnostic and therapeutic approaches. Additional research projects of the lab include pathomechanisms of transplant vasculopathy, mechanisms of acute cardiac allograft rejection and effects of cardiovascular inflammation on myocardial function.

Recent selected publications:
Korosoglou, G., Gleissner, C.A., Giannitsis, E., Katus, H.A. 2012.
Subclinical atherosclerosis and chronic troponin elevation: the voice of silence in diabetics. J Am Coll Cardiol, 60(2):167-8.

Erbel, C., Dengler, T.J., Wangler, S., Bea, F. Wambsganss,  N., Hakimi, M., Böckler, D., Katus, H.A., Gleissner, C.A. 2010.
Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability. Basic Res Cardiol, 106(1), 125-34.

Gleissner, C.A., Little, K.M., Ley, K. 2010.
CXCL4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol, 184 (9), 4810-8.

Schulz, C., Heuschen, N.V., Fröhlich, T., Lorenz, M., Pfeiler, S., Gleissner, C.A., Kremmer, E., Kessler, M., Khandogau A.G., Engelmann, B., Ley, K., Massberg, S., Arnold, G.J. 2010.
Identification of novel downstream targets of platelet glycoprotein VI activation. Blood, 115(20):4102-10.

Gleissner, C.A., Shaked, I., Erbel, C., Böckler, D., Katus, H.A., Ley, K. 2010.
CXCL4 induces CD163- macrophages: Functional implication in atherosclerosis. Circ Res, 106(1):203-11.

 

Gleissner group members Group members:
Christian A. Gleissner, MD
Christian Erbel, MD
Susanne Wangler, MD
Mohammad Akhavanpoor
Lujia Zhang
Nadine Wambsganss (Technician)