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Christoph Scheiermann

Christoph Scheiermann, PhD

Walter-Brendel-Center of Experimental Medicine
Ludwig-Maximilians-Universität
Marchioninistr. 27
81377 München
Germany
+49-89-2180-76537

Email: christoph.scheiermann@med.uni-muenchen.de

Websites: 
www.wbex.med.uni-muenchen.de/pages/principal_c_scheiermann.htm

www.sfb914.med.uni-muenchen.de/news/news/20130219_scheiermann_enoether/index.html

 

Vessel enwrapped by sympathetic nervesOur group exists since March 2013. We are very interested in how neural inputs can regulate leukocyte trafficking. We have thus far investigated the role that sympathetic nerves play in this process.

In particular, we found that local sympathetic tone regulates leukocyte recruitment to tissues, being high at times of physical activity and low during rest. Thus, leukocyte migration underlies a circadian rhythm, an oscillation that occurs within a ~24h cycle.

 

Rhythms in leukocyte trafficking

 

We study leukocyte migration patterns using various intravital microscopy techniques in different tissues. Specifically, we aim to address which promigratory factors control these observed circadian rhythms and whether they can be altered by surgical, pharmacological or genetic interventions.

 

 

The anticipated results will therefore provide new insight into our understanding of leukocyte trafficking with the potential to develop new therapies for inflammatory diseases using time-sensitive interventions.

 

Recent publications:

Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013). Circadian control of the immune system. Nat Rev Immunol, 13(3), 190-198.

Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013). Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. Annu Rev Immunol, 31, 285-316.

Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A., Jang, J. E., Zhang, D., Hashimoto, D., Merad, M. & Frenette, P. S. (2012). Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity, 37(2), 290-301.

Almeida, C. B., Scheiermann, C., Jang, J. E., Prophete, C., Costa, F. F., Conran, N., & Frenette, P. S. (2012). Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Blood, 120(14), 2879-2888.

Chow, A., Lucas, D., Hidalgo, A., Mendez-Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., Tanaka, M., Merad, M. & Frenette, P. S. (2011). Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med, 208(2), 261-271.

Scheiermann, C., Kunisaki, Y., Jang, J. E., & Frenette, P. S. (2010). Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr Opin Hematol, 17(1), 25-30.

Scheiermann, C., Colom, B., Meda, P., Patel, N. S., Voisin, M. B., Marrelli, A., Woodfin, A., Pitzalis, C., Thiemermann, C., Aurrand-Lions, M., Imhof, B. A. & Nourshargh, S. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol, 29(10), 1509-1515.

Scheiermann, C., Meda, P., Aurrand-Lions, M., Madani, R., Yiangou, Y., Coffey, P., Salt, T. E., Ducrest-Gay, D., Caille, D., Howell, O., Reynolds, R., Lobrinus, A., Adams, R. H., Yu, A. S., Anand, P., Imhof, B. A. & Nourshargh, S. (2007). Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science, 318(5855), 1472-1475.